방사선의학 웹진

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Abstract
The unique ability of chlorophyll derivatives to accumulate in tumor tissues and cause a photodynamic effect under laser radiation has been successfully used in photodynamic therapy (PDT). Previous research on modified peripheral substituents in chlorophyll showed that the presence and position of substituents in chlorin derivatives remarkably affect biological activities. Herein, we synthesized methyl pyropheophorbide-a (MPPa) derivatives, which are chlorophyll-a derivatives with heterocyclic aromatic substituents or pyrazole moieties on the peripheral positions. Then, we examined the PDT effects of these new derivatives in vitro and in vivo.

Affiliations

Tae Heon Leea1,Hye Jeong Kim a1,Bo-Ra Lee b1, Sang Bong Lee d1, Da-Sol Lee b1, Ye Ri Han c, Kil Soo Kim bd, Young Kyu Song a, Young Key Shim a, Su-Jin Park f, Dong-Won Kim g, Yong Hyun Jeon be

a
Research Center of Dr. i&B Co., DaeJeon, Republic of Korea
b
Laboratory Animal Center, Daegu-Gyeongbuk Medical Innovation Foundation, 80 Cheombok-ro Dong-gu Daegu, Republic of Korea
c
New Drug Development Center, Daegu-Gyeongbuk Medical Innovation Foundation, 80 Chembok-ro Dong-gu Daegu, Republic of Korea
d
College of Veterinary Medicine, Kyungpook National University, Daegu 41566, Republic of Korea
e
Vaccine Commercialization Center, Gyeongbuk Institute for Bioindustry, 88, Saneodanjigil, pungsan-eup, Andong-si, Gyeongbuk, 36618, Republic of Korea
f
Woogene B&G Co., LTD., 230, Jeongmunsongsan-ro, Yanggam-myeon, Hwasung-si Gyonggi-do, Republic of Korea
g
OSP Co., LTD., 11, Saneopdanji-ro 2-gil, Seongdong-myeon, Nonsan-si, Chungcheongnam-do, Republic of Korea