글로벌 연구동향
분자영상 및 방사화학
- 2018년 11월호
[Mol Pharm.] Immense Insulin Intestinal Uptake and Lymphatic Transport Using Bile Acid Conjugated Partially Uncapped Liposome.가톨릭대학교 / 김경섭, 배유한*
- 출처
- Mol Pharm.
- 등재일
- 2018 Oct 1
- 저널이슈번호
- 15(10):4756-4763. doi: 10.1021/acs.molpharmaceut.8b00708. Epub 2018 Aug 29.
- 내용
Abstract
We provide immense insulin absorption from the gastrointestinal tract, combining apical sodium-dependent bile acid transporter-mediated intestinal uptake and the lymphatic transport pathway. This strategy has proven to employ chondroitin sulfate- g-taurocholic acid coated, insulin-loaded partially uncapped liposome (IPUL-CST) for type 1 diabetes mellitus (T1DM) treatment. The loading efficiency of insulin in IPUL-CST increased significantly from 33% to 75% via the partially uncapped liposome preparation method. Moreover, the IPUL-CST revealed an improved insulin protection efficacy in GIT simulated pH and digestive enzyme conditions. The high dose of IPUL-CST in the small intestine was detected 4 h post-oral administration using ex vivo optical imaging and fluorescence intensity. The IPUL-CST exhibited significantly enhanced intestinal absorption (oral bioavailability, 34%; Tmax, 9 h) and reduced blood glucose levels for 16 h in T1DM. The results demonstrated that the new investigated IPUL-CST is a promising carrier for oral insulin delivery.
Author informationKim KS1, Kwag DS2, Hwang HS1, Lee ES2, Bae YH1.
1
Department of Pharmaceutics and Pharmaceutical Chemistry , University of Utah , Salt Lake City , Utah 84112 , United States.
2
Department of Biotechnology , The Catholic University of Korea , 43-1 Yeokgok 2-dong, Wonmi-gu , Bucheon , Gyeonggi-do 420-743 , Republic of Korea.
- 키워드
- chondroitin sulfate coated liposome; long acting insulin; massive intestinal absorption; oral insulin delivery; taurocholic acid
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