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Abstract
Objective. The purpose of this study is to assess its human images and its unique capabilities such as the 'on demand' higher spatial resolution and multi-spectral imaging of photon-counting-detector (PCD)-CT.Approach. In this study, the FDA 510(k) cleared mobile PCD-CT (OmniTom Elite) was used. To this end, we imaged internationally certified CT phantoms and a human cadaver head to evaluate the feasibility of high resolution (HR) and multi-energy imaging. We also demonstrate the performance of PCD-CT via first-in-human imaging by scanning three human volunteers.Main results. At the 5 mm slice thickness, routinely used in diagnostic head CT, the first human PCD-CT images were diagnostically equivalent to the EID-CT scanner. The HR acquisition mode of PCD-CT achieved a resolution of 11 line-pairs (lp)/cm as compared to 7 lp cm-1using the same kernel (posterior fossa-kernel) in the standard acquisition mode of EID-CT. For the quantitative multi-energy CT performance, the measured CT numbers in virtual mono-energetic images (VMI) of iodine inserts in the Gammex Multi-Energy CT phantom (model 1492, Sun Nuclear Corporation, USA) matched the manufacturer reference values with mean percent error of 3.25%. Multi-energy decomposition with PCD-CT demonstrated the separation and quantification of iodine, calcium, and water.Significance. PCD-CT can achieve multi-resolution acquisition modes without physically changing the CT detector. It can provide superior spatial resolution compared with the standard acquisition mode the conventional mobile EID-CT. Quantitative spectral capability of PCD-CT can provide accurate, simultaneous multi-energy images for material decomposition and VMI generation using a single exposure.

Affiliations

Su-Jin Park 1, Junyoung Park 1, Doil Kim 1, Duhgoon Lee 2, Chang-Lae Lee 1, Ibrahim Bechwati 2, Dufan Wu 3, Rajiv Gupta 3, Jinwook Jung 1
1Health & Medical Equipment Business, Samsung Electronics Co., Ltd, 129, SamSung-ro, Yeongtong-gu, Suwon-si, Gyeonggi-do, 16677, Republic of Korea.
2Samsung NeuroLogica, 14 Electronics Ave, Danvers, MA 01923, United States of America.
3Massachusetts General Hospital, Radiology, 55 Fruit St, Boston, MA 02114, United States of America.