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Abstract
Purpose: Although escitalopram is known to be an effective drug for adult depression, its disease-modifying efficacy on adolescents remains controversial. The present study aimed to evaluate the therapeutic effect of escitalopram on behavioral aspects as well as functional neural circuits by means of positron emission tomography.

Procedures: To generate the animal models of depression, restraint stress was used during the peri-adolescent period (RS group). Thereafter, escitalopram was administered after the end of stress exposure (Tx group). We performed NeuroPET studies of glutamate, glutamate, GABA, and serotonin systems.

Results: The Tx group showed no body weight change compared to the RS group. In the behavioral tests, the Tx group also displayed the similar time spent in open arms and immobility time to those for RS. In the PET studies, brain uptake values for the Tx group revealed no significant differences in terms of glucose, GABAA, and 5-HT1A receptor densities, but lower mGluR5 PET uptake compared to the RS group. In the immunohistochemistry, the Tx group showed the significant loss of neuronal cells in the hippocampus compared to the RS group.

Conclusion: The administration of escitalopram had no therapeutic effect on the adolescent depression.

우울증 그룹과 에스시탈로프람 치료 그룹에서의 신경 PET 영상 비교와 사후 조직 부검 결과

Affiliations

Se Jong Oh # 1, Namhun Lee # 1, Kyung Rok Nam 1, Kyung Jun Kang 1, Sang Jin Han 1, Jae Yong Choi 2 3
1Division of Applied RI, Korea Institute of Radiological and Medical Sciences, Seoul, South Korea, 01812.
2Division of Applied RI, Korea Institute of Radiological and Medical Sciences, Seoul, South Korea, 01812. smhany@kirams.re.kr.
3Radiological and Medico-Oncological Sciences, University of Science and Technology (UST), Seoul, South Korea, 01812. smhany@kirams.re.kr.
#Contributed equally.