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Abstract
We report the direct radiofluorosulfurylation method for the synthesis of 18F-labeled fluorosulfuryl derivatives from phenols and amines using an [18F]FSO2+ transfer agent generated in situ. Nucleophilic radiofluorination is achieved even in a hydrous organic medium, obviating the need for azeotropic drying and the use of cryptands. This unprecedented, operationally simple isotopic functionalization facilitates the reliable production of potential radiotracers for positron emission tomography, rendering facile access to SuFEx radiochemistry.

Affiliations

Min Pyeong Kim 1, Hojin Cho 2, Swatilekha Kayal 1, Min Ho Jeon 1, Jeong Kon Seo 3, Jeongmin Son 2, Jinsil Jeong 2, Sung You Hong 1, Joong-Hyun Chun 2
1Department of Chemistry and Department of Chemical Engineering, Graduate School of Carbon Neutrality, Ulsan National Institute of Science and Technology (UNIST), Ulsan 44919, Republic of Korea.
2Department of Nuclear Medicine, Yonsei University College of Medicine, Seoul 03722, Republic of Korea.
3UNIST Central Research Facility, Ulsan National Institute of Science and Technology (UNIST), Ulsan 44919, Republic of Korea.