분자영상 및 방사화학

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  • [Theranostics] Deep tissue photoacoustic imaging of nickel(II) dithiolene-containing polymeric nanoparticles in the second near-infrared window니켈디티올렌 함유 고분자 나노입자의 심부조직 광음향영상

    전남대, 포항공대 / 박별이, 이경민, 이창호*, 김형우*, 김철홍*

  • 출처
    Theranostics
  • 등재일
    2020
  • 저널이슈번호
    10(6): 2509-2521. doi:10.7150/thno.39403
  • 내용

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    Abstract

    Photoacoustic imaging is gaining great attention in the medical world due to its significant potential for clinical translation. Light excitation in the second near-infrared (NIR-II) window (1000-1350 nm) has resolution and penetration depth suitable for several clinical applications. However, the significant challenge exists for clinical translation because of the absence of notable intrinsic chromophores in this clinically significant optical range to generate diagnostic images.

    Methods: We present newly developed a biocompatible nickel dithiolene-based polymeric nanoparticle (NiPNP), which have a strong and sharp absorption peak at 1064 nm, as a photoacoustic contrast agent to boost specific absorbance in the NIR-II window for in vivo deep tissue imaging.

    Results: We confirm the enhanced PA signal by NiPNP's strong light absorption in the NIR-II window (287% higher than that of NIR-I) and deep tissue imaging capability (~5.1 cm) through in vitro experiment. We have successfully acquired diagnostic-quality in vivo photoacoustic images in deep tissue (~3.4 cm) of sentinel lymph nodes, gastrointestinal tracts, and bladders of live rats by using clinically viable imaging system.

    Conclusions: Our results prove that with strong absorption in the NIR-II window and with deeper imaging depth, the clinical translation of photoacoustic imaging with NiPNP is feasible for preclinical studies and thus would facilitate further clinical investigations.

     

    Author information

    Byullee Park1*, Kyung Min Lee2,6*, Suhyeon Park3, Misun Yun4, Hak-Jong Choi4, Jeesu Kim1, Changho Lee3,5  , Hyungwoo Kim6  , Chulhong Kim1

    1.Departments of Creative IT Engineering, Electrical Engineering, and Mechanical Engineering, Pohang University of Science and Technology (POSTECH), 77 Cheongam-ro, Pohang 37673, Republic of Korea.
    2. Department of Materials Science and Engineering, College of Engineering, Seoul National University, Seoul 08826, Republic of Korea.
    3. Interdisciplinary Program of Molecular Medicine, Chonnam National University, 77 Yongbong‐ro, Buk‐gu, Gwangju 61186, Republic of Korea.
    4. Microbiology and Functionality Research Group, World Institute of Kimchi, 86 Kimchi-ro, Gwangju 61755, Republic of Korea.
    5. Department of Nuclear Medicine, Chonnam National University Medical School & Hwasun Hospital, 264, Seoyang-ro, Hwasun-eup, Hwasun-gun, Jeollanam-do 58128, Republic of Korea.
    6. School of Polymer Science and Engineering, Chonnam National University, 77 Yongbong-ro, Buk-gu, Gwangju 61186, Republic of Korea.
    * These authors contributed equally to this work.

  • 키워드
    Photoacoustic imaging, Deep tissue imaging, Nickel dithiolene complex, Polymeric nanoparticle, Second near-infrared window.
  • 편집위원

    근적외선(NIR)을 이용하는 생체 형광영상은 1 cm 깊이의 시그널도 얻기 힘든 단점이 있다. 이와는 달리, NIR-II 파장대(1000-1350 nm) 를 이용하는 광음향 영상(photoacoustic imaging)은 대략 5 cm 깊이까지의 생체를 영상화 할 수 있다. 이 논문은 1064 nm에서 빚 흡수를 보이는 생체 적합한 nickel dithiolene 기반의 나노물질(nickel dithiolene-based polymeric nanoparticle, NiPNP)의 개발 및 이를 이용한 동물에서의 생체 광음향 영상 결과를 보여줌으로써 임상에서의 활용 가능성을 제시하고 있다.

    2020-04-01 16:32:08

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