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Abstract
We synthesized [18F]trifluoromethyl‐l‐tryptophan ([18F]CF3‐l‐Trp) using Cu(I)‐mediated [18F]trifluoromethylation to image serotonergic system. Radiochemical yield was 6 ± 1.5% (n = 9), and radiochemical purity was over 99%. The molar activity was 0.44 to 0.76 GBq/μmol. [18F]CF3‐l‐Trp was stable for up to 6 hours in mouse and human sera at 37°C. Protein‐binding was 0.26 ± 0.03% and 0.34 ± 0.02% in human and mouse serum at 60 minutes, respectively. In conclusion, enantiopure [18F]CF3‐l‐Trp was synthesized as a feasible imaging agent for the serotonergic system.

Ho Young Kim , Ji Youn Lee , Yun‐Sang Lee , Jae Min Jeong