KIST / 고영지, 권익찬*
Abstract
Receptor targeted imaging has emerged as a promising tools for imaging tumor tissues. Receptor targeted molecular imaging confers critical information on clinicians including tumor location, expression level of certain receptors, and biological process, which enables early diagnosis and treatment of tumor to control cancer mortality. Receptor targeted probe design is a key to successfully deliver accurate information through many imaging modalities. When designing receptor targeted imaging probes, a variety of targeting receptors and imaging modalities are selected depending on type of cancer because overexpression of receptors are variant among tumors and each imaging modality has advantages and disadvantages. Subsequently selecting appropriate tumor targeting strategies is critical to efficiently visualize tumor of interest. In this review, we presented the strategies commonly used for designing receptor targeted probes and summarized the recent studies that implemented each strategies.
Author information
Ko YJ1, Kim WJ1, Kim K1, Kwon IC2.
1
KU-KIST Graduate School of Converging Science and Technology, Korea University, 145 Anam-ro, Seongbuk-gu, Seoul 02841, Republic of Korea; Biomedical Research Institute, Korea Institute of Science and Technology (KIST), Seoul 02792, Republic of Korea.
2
KU-KIST Graduate School of Converging Science and Technology, Korea University, 145 Anam-ro, Seongbuk-gu, Seoul 02841, Republic of Korea; Biomedical Research Institute, Korea Institute of Science and Technology (KIST), Seoul 02792, Republic of Korea. Electronic address: ikwon@kist.re.kr.
편집위원
수용체를 표적으로 하는 분자영상은 종양조직의 위치, 진행정도, 발현 등에 관한 정보를 제공하여 초기진단과 치료에 매우 효과적인 기법이며, 적절한 probe의 제작이 핵심과정이다. 본 리뷰 논문은 수용체-표적 probe 제작의 전략과 최근 연구 성과에 대해 소개하고 있다.
2019-08-30 10:05:59
편집위원2
수용체를 표적으로하는 치료 및 영상법에 대한 연구는 최근 들어 더 많은 관심을 받고 있다. 이 논문은 다양한 영상법(핵의학, MRI, 초음파, 광학)을 이용한 수용체 표적 영상 연구의 최신 기술 및 결과를 전반적으로 리뷰하면서, 관련 연구자로 하여금 어떤 전략을 통해 수용체 표적 영상을 할 수 있을지 의견을 제시하고 있다.
2019-08-30 10:07:13