아주대, KIST / 추연정, 김은하*, 이상희*
그림 SiR-Mito 11의 화학구조와 뇌종양 세포인 Glioma Cell에 대한 테라노스틱스적 (Thernostics) 활용에 관한 모식도
Abstract
Because mitochondria are essential organelles for regulating energy homeostasis and intrinsic apoptosis, the perturbation of mitochondrial functions has been considered as an anticancer treatment. In this study, a new near-infrared (NIR) fluorescent probe, SiR-Mito11 was developed as a theragnostic agent for brain tumor by targeting mitochondria. SiR-Mito11 exhibited potential anticancer activity against glioma cells but tolerance in normal neuronal cells. We further confirmed that the selective accumulation of SiR-Mito11 in glioma cells disrupted mitochondria membrane potential, followed by apoptotic cell death.
Author information
Chu Y1,2, Shin MC1, Sung J1, Park J3, Kim E1, Lee S2.
1
Department of Molecular Science and Technology , Ajou University , Suwon 16499 , Republic of Korea.
2
Center for Neuro-Medicine , Brain Science Institute, Korea Institute of Science and Technology , Seoul 02792 , Republic of Korea.
3
Department of Chemistry , Kangwon National University . Chuncheon 24341 , Republic of Korea.