글로벌 연구동향
방사선생물학
- 2018년 05월호
[J Tissue Eng Regen Med.] Substance-P and transforming growth factor-β in chitosan microparticle-pluronic hydrogel accelerates regenerative wound repair of skin injury by local ionizing radiation.KIRAMS / 박상준, 김천호*
- 출처
- J Tissue Eng Regen Med.
- 등재일
- 2018 Apr
- 저널이슈번호
- 12(4):890-896. doi: 10.1002/term.2445. Epub 2017 Jun 29.
- 내용
Abstract
Clinical irradiation therapy for cancer could increase the risk of localized wound complications. This study was conducted to evaluate the potential use of a chitosan microparticle-pluronic F127 (CSMP-PF) hydrogel complex containing bioactive molecules, substance P and transforming growth factor-β1, to regeneratively repair skin damaged by local ionizing radiation (IR). The BALB/c/bkl mice were locally irradiated to their limbs with a single 40 Gy dose of Co-60 γ rays to induce a skin injury. The morphological characteristics of the chitosan microparticles were analysed by scanning electron microscopy. The amounts of bioactive molecules taken up and released by the CSMP-PF hydrogel complex were measured. Haematoxylin and eosin staining of IR-damaged skin showed acanthosis and hyperkeratosis in the epidermis; and damage to hair follicles/skin appendages and adipose tissue, as well as panniculus carnosus, in the dermis. Injection of the CSMP-PF hydrogel complex into IR-damaged skin resulted in skin repair, suggesting that the complex has potential for use in the regenerative repair of IR-damaged skin.
Author informationPark SJ1, Cho W1,2, Kim MS1, Gu BK1, Kang CM1, Khang G3, Kim CH1.
1
Laboratory of Tissue Engineering, Korea Institute of Radiological and Medical Sciences, Seoul, Korea.
2
Department of Genetic Engineering, Kyung Hee University, Yongin, Korea.
3
Department of Polymer-Nano Science and Technology, Polymer Fusion Research Center, Chonbuk National University, Jeonju, Korea.
- 키워드
- bioactive molecule; chitosan; hydrogel; radiation; repair; skin
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