글로벌 연구동향
의학물리학
- 2020년 04월호
[IEEE Trans Med Imaging.] Dynamic In Vivo X-ray Fluorescence Imaging of Gold in Living Mice Exposed to Gold Nanoparticles.서울대 / 정성문, 예성준*
- 출처
- IEEE Trans Med Imaging.
- 등재일
- 2020 Feb
- 저널이슈번호
- 39(2):526-533. doi: 10.1109/TMI.2019.2932014. Epub 2019 Jul 30.
- 내용
Abstract
Dynamic in vivo biodistribution of gold nanoparticles (GNPs) in living mice was first successfully acquired by a pinhole X-ray fluorescence (XRF) imaging system using polychromatic X-rays. The system consisted of fan-beam X-rays to stimulate GNPs and a 2D cadmium zinc telluride (CZT) gamma camera to collect K-shell XRF photons emitted from the GNPs. 2D XRF images of kidney slices of three Balb/C mice were obtained within 2 minutes of irradiation per slice. 40 mg of GNPs suspended in a 0.2 mL phosphate-buffered saline was injected into the mice via a tail vein. The mice were scanned over a 60 min period after the injection of GNPs in order to acquire a dynamic biodistribution of GNPs. The concentrations of GNPs measured by the CZT gamma camera were then validated by inductively coupled plasma atomic emission spectroscopy and ex vivo L-shell XRF measurements using a silicon drift detector. The GNP concentrations in the right-side kidneys were 1.58% by weight (wt%) at T =0 min and 0.77 wt% at T=60 min after the injection. This investigation showed a dramatically reduced scan time and imaging dose. Hence, we conclude that dynamic in vivo XRF imaging of GNPs is technically feasible in a benchtop system. The developed pinhole XRF imaging system can be a potential molecular imaging modality for metal nanoparticles to emerge as a radiosensitizer and a drug-delivery agent.Author information
Jung S, Kim T, Lee W, Kim H, Kim HS, Im HJ, Ye SJ.
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