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의학물리학
- 2017년 03월호
[Oncotarget.] Correlation analysis between 2D and quasi-3D gamma evaluations for both intensity-modulated radiation therapy and volumetric modulated arc therapy.서울의대 / 김정인, 최창헌, 우홍균, 김진호, 박종민*
- 출처
- Oncotarget.
- 등재일
- 2017 Jan 17
- 저널이슈번호
- 8(3):5449-5459. doi: 10.18632/oncotarget.12279.
- 내용
AbstractThe aim of this work was to investigate correlations between 2D and quasi-3D gamma passing rates. A total of 20 patients (10 prostate cases and 10 head and neck cases, H&N) were retrospectively selected. For each patient, both intensity-modulated radiation therapy (IMRT) and volumetric modulated arc therapy (VMAT) plans were generated. For each plan, 2D gamma evaluation with radiochromic films and quasi-3D gamma evaluation with fluence measurements were performed with both 2%/2 mm and 3%/3 mm criteria. Gamma passing rates were grouped together according to delivery techniques and treatment sites. Statistical analyses were performed to examine the correlation between 2D and quasi-3D gamma evaluations. Statistically significant difference was observed between delivery techniques only in the quasi-3D gamma passing rates with 2%/2 mm. Statistically significant differences were observed between treatment sites in the 2D gamma passing rates (differences of less than 8%). No statistically significant correlations were observed between 2D and quasi-3D gamma passing rates except the VMAT group and the group including both IMRT and VMAT with 3%/3 mm (r = 0.564 with p = 0.012 for theVMAT group and r = 0.372 with p = 0.020 for the group including both IMRT and VMAT), however, those were not strong. No strong correlations were observed between 2D and quasi-3D gamma evaluations.
Kim JIAuthor information
Kim JI1,2,3, Choi CH1,2,3,4, Wu HG1,2,3,5, Kim JH1,2,3, Kim K6, Park JM1,2,3,4.1 Department of Radiation Oncology, Seoul National University Hospital, Seoul, Republic of Korea.
2 Institute of Radiation Medicine, Seoul National University Medical Research Center, Seoul, Republic of Korea.
3 Biomedical Research Institute, Seoul National University College of Medicine, Seoul, Republic of Korea.
4 Center for Convergence Research on Robotics, Advanced Institutes of Convergence Technology, Suwon, Republic of Korea.
5 Department of Radiation Oncology, Seoul National University College of Medicine, Seoul, Republic of Korea.
6 Department of Radiation Oncology, Ewha Womans University School of Medicine, Seoul, Republic of Korea.
- 키워드
- 2D gamma evaluation; intensity-modulated radiation therapy; pre-treatment patient-specific quality assurance; quasi-3D gamma evaluation; volumetric modulated arc therapy
- 연구소개
- 임상에서 IMRT/VMAT 환자특이적 정도관리를 위해 널리 사용되고 있는 2D 감마분석법의 성능평가를 위해, VMAT 치료계획을 대상으로 2D 감마분석결과와 quasi-3D 감마분석결과의 상관관계를 연구한 논문입니다. 분석 결과, 2D 감마분석결과와 quasi-3D 감마분석결과 사이에 유의한 상관관계가 없음을 확인했습니다. 이는 더욱 많은 정보를 가지고 있는 quasi-3D 감마분석에 비해, 2D 감마분석이 정보량이 부족했기 때문으로 생각됩니다. 따라서, 임상에서 보다 정밀하고 민감한 환자특이적 정도관리를 수행하기 위하여 quasi-3D 감마분석법을 사용하는 것이 권고됩니다.
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