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Abstract
This study evaluated the prognostic significance of FDG PET/CT in patients with nodal peripheral T-cell lymphoma (PTCL). We retrospectively reviewed patients with histologically confirmed nodal PTCL who underwent FDG PET/CT at baseline, after three cycles of first-line chemotherapy (interim), and at the end of therapy. Response was assessed visually using the Deauville 5-point scale (D5PS); scores of 1, 2, and 3 were considered PET-negative, and scores of 4 and 5 were considered PET-positive. The associations between FDG PET/CT findings and survival were assessed using Cox regression analysis. A total of 79 patients (44 males and 35 females; median age 56 years) were included in this study. In response assessment, 17 (22%) had an interim PET-positive result and 10 (13%) had an end-of-therapy PET-positive result. During a median follow-up of 50 months, 37 patients (47%) presented with disease progression and 30 patients (38%) died. The estimated 5-year progression-free survival (PFS) and overall survival (OS) were 57% and 64%, respectively. An interim PET-positive result was the only significant indicator of PFS. Higher International Prognostic Index and end-of-therapy PET-positive result were significant independent prognostic factors of OS. Interim and end-of-therapy FDG PET/CT responses based on D5PS are meaningful in predicting the outcomes of patients with nodal PTCL.

Affiliations

Woo Hee Choi 1, Eun Ji Han 1, Joo Hyun O 1, Eun Kyoung Choi 1, Joon-Il Choi 2, Gyeongsin Park 3, Byung-Ock Choi 4, Young-Woo Jeon 5, Gi-June Min 5, Seok-Goo Cho 5; Catholic University Lymphoma Group
1Division of Nuclear Medicine, Department of Radiology, College of Medicine, The Catholic University of Korea, Seoul 06591, Republic of Korea.
2Department of Radiology, College of Medicine, The Catholic University of Korea, Seoul 06591, Republic of Korea.
3Department of Hospital Pathology, College of Medicine, The Catholic University of Korea, Seoul 06591, Republic of Korea.
4Department of Radiation Oncology, College of Medicine, The Catholic University of Korea, Seoul 06591, Republic of Korea.
5Department of Hematology, College of Medicine, The Catholic University of Korea, Seoul 06591, Republic of Korea.