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  • [Sci Rep.] Diagnostic Accuracy and Confidence of [18F] FDG PET/MRI in Comparison With PET or MRI Alone in Head and Neck Cancer

    서울대병원 / 박지상,천기정*, 김지훈*

  • 출처
    Sci Rep.
  • 등재일
    2020 Jun 11
  • 저널이슈번호
    10(1):9490. doi: 10.1038/s41598-020-66506-8.
  • 내용

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    Abstract
    The usefulness of PET/MRI in head and neck malignancy has not been fully elucidated. The purpose of our study was to evaluate the diagnostic accuracy and confidence of PET/MRI in comparison with PET or MRI alone. This study included 73 consecutive patients who underwent [18F] FDG PET/MRI in head and neck under the suspicion of malignancy. A neuroradiologist and a nuclear medicine specialist reviewed MRI and PET images, respectively and independently, followed by a consensus review of PET/MRI one month later. For 134 lesions, accuracy and confidence were compared among PET, MRI, and PET/MRI. For lesion base, PET/MRI had a sensitivity of 85.7%, a specificity of 89.1%, a PPV of 89.6%, a negative predictive value of 85.1%, and an accuracy of 87.3%. AUCs of PET/MRI per lesion (0.926) and per patient (0.934) for diagnosing malignancy were higher than PET (0.847 and 0.747, respectively) or MRI (0.836 and 0.798, respectively) alone (P < 0.05). More than 80% of the cases (111/134) showed diagnostic concordance between PET and MRI. PPV of PET/MRI was higher in malignant concordant cases (93.2%, 55/59) than in discordant cases (62.5%, 5/8) (p = 0.040). Confident scoring rate in malignant concordant cases was higher on PET/MRI (96.6%, 57/59) than on MRI (76.3%, 45/59) (p = 0.003). In conclusion, compared with PET or MRI alone, PET/MRI presents better diagnostic performance in accuracy and confidence for diagnosis of malignancy. PET/MRI is useful in patients with head and neck cancer.

     


    Affiliations

    Jisang Park  1 , Kyoungjune Pak  2 , Tae Jin Yun  3 , Eun Kyoung Lee  4 , Inseon Ryoo  5 , Ji Ye Lee  3 , Inpyeong Hwang  3 , Roh-Eul Yoo  3 , Koung Mi Kang  3 , Seung Hong Choi  3 , Chul-Ho Sohn  3 , Gi Jeong Cheon  6 , Ji-Hoon Kim  7
    1 Department of Radiology, Konkuk University Chungju Hospital, 82, Gukwondae-ro, Chunju, Chungcheongbuk-do, 27376, Republic of Korea.
    2 Department of Nuclear medicine, Pusan National University Hospital, 179, Guduk-ro, seo-gu, Pusan, 49241, Republic of Korea.
    3 Department of Radiology, Seoul National University Hospital, 101, Daehak-ro, Jongno-gu, Seoul, 03080, Republic of Korea.
    4 Department of Radiology, Seoul National University Hospital Healthcare System Gangnam Center, Gangnam Finance Center 152, Teheran-ro, Gangnam-gu, Seoul, 06236, Republic of Korea.
    5 Department of Radiology, Korea University Guro Hospital, 148, Gurodong-ro, Guro-gu, Seoul, 08308, Republic of Korea.
    6 Department of Nuclear medicine, Seoul National University Hospital, 101, Daehak-ro, Jongno-gu, Seoul, 03080, Republic of Korea. larrycheon@gmail.com.
    7 Department of Radiology, Seoul National University Hospital, 101, Daehak-ro, Jongno-gu, Seoul, 03080, Republic of Korea. jihnkim@gmail.com.

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