글로벌 연구동향
핵의학
- 2020년 03월호
[Diabetes Obes Metab.] Striatal dopamine transporter changes after glucose loading in humans.부산대병원 / 서성호, 박경준*
- 출처
- Diabetes Obes Metab.
- 등재일
- 2020 Jan
- 저널이슈번호
- 22(1):116-122. doi: 10.1111/dom.13872. Epub 2019 Sep 30.
- 내용
Abstract
AIMS:
The dopamine transporter (DAT) actively translocates dopamine that is released from the presynaptic neurons across the membranes of nerve terminals into the extracellular space. We hypothesized that glucose loading-induced changes in striatal DAT levels could be associated with food intake in humans.MATERIALS AND METHODS:
An intravenous bolus injection of 18 F-FP-CIT was administered after infusion of glucose or placebo (normal saline), and emission data were acquired over 90 minutes in 33 healthy males. For a volume-of-interest-based analysis, an atlas involving sub-striatal regions of ventral striatum (VST), caudate nucleus and putamen was applied. DAT availability and binding potential (BPND ) were measured using a simplified reference tissue method with cerebellum as the reference.RESULTS:
The glucose-loaded BPND from the VST negatively correlated with body mass index (BMI), whereas the placebo-loaded BPND from the VST did not. After loading with glucose, there were substantial increases in BPND s: 18.3%, 71.7% and 34.0% on average in the VST, caudate nucleus and putamen, respectively.CONCLUSION:
Striatal DAT changes after glucose loading, and BMI is associated with glucose-loaded DAT availability, not with placebo-loaded DAT availability. DAT might have a role in the reward system of eating behavior.
Author informationPak K1, Seo S2,3, Kim K1, Lee MJ4, Shin MJ5, Suh S6, Im HJ7, Park JJ8, Kim SJ9, Kim IJ1.
1
Department of Nuclear Medicine and Biomedical Research Institute, Pusan National University Hospital, Busan, Republic of Korea.
2
Department of Neuroscience, College of Medicine, Gachon University, Incheon, Republic of Korea.
3
Neuroscience Research Institute, Gachon University, Incheon, Republic of Korea.
4
Department of Neurology, Pusan National University Hospital, Busan, Republic of Korea.
5
Department of Rehabilitation Medicine, Pusan National University Hospital, Busan, Republic of Korea.
6
Department of Internal Medicine, Dong-A University College of Medicine, Busan, Republic of Korea.
7
Graduate School of Convergence Science and Technology, Seoul National University, Seoul, Republic of Korea.
8
Division of Sport Science, Pusan National University, Busan, Republic of Korea.
9
Department of Nuclear Medicine, Pusan National University Yangsan Hospital, Yangsan, Republic of Korea.
- 키워드
- dopamine plasma membrane transport proteins; glucose; obesity; reward
- 연구소개
- 인간의 식이행동에서의 뇌의 역할에 대한 연구입니다. 건강한 성인남자에게 각각 glucose 및 placebo (normal saline) 부하 후, 18F-FP-CIT PET을 이용하여 dopamine transporter (DAT)의 변화를 확인하였습니다. glucose loading 이후, placebo loading에 비해서, 18~71% (영역별)의 DAT 증가를 확인하였습니다. Insulin을 통한 DAT의 변화가 reward system에서 중요한 역할을 하고 있음을 짐작할 수 있었습니다.
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