글로벌 연구동향
핵의학
- 2020년 02월호
[IEEE Trans Med Imaging.] In Vivo Measurement of Brain Tissue Response After Irradiation: Comparison of T2 Relaxation, Apparent Diffusion Coefficient, and Electrical Conductivity.경희대 / 박지애, 우응제*
- 출처
- IEEE Trans Med Imaging.
- 등재일
- 2019 Dec
- 저널이슈번호
- 38(12):2779-2784. doi: 10.1109/TMI.2019.2913766. Epub 2019 Apr 29.
- 내용
Abstract
Radiation therapy (RT) has been widely used as a powerful treatment tool to address cancerous tissues because of its ability to control cell growth. Its ionizing radiation damages the DNA of cancerous tissues, leading to cell death. Medical imaging, however, still has limitations regarding the reliability of its assessment of tissue response and in predicting the treatment effect because of its inability to provide contrast information on the gradual, minute tissue changes after RT. A recently developed magnetic resonance (MR)-based conductivity imaging method may provide direct, highly sensitive information on this tissue response because its contrast mechanism is based on the concentration and mobility of ions in intracellular and extracellular spaces. In this feasibility study, we applied T2-weighted, diffusion-weighted, and electrical conductivity imaging to mouse brain, thus, using the MR imaging to map the tissue response after radiation exposure. To evaluate the degree of response, we measured the T2 relaxation, apparent diffusion coefficient (ADC), and electrical conductivity of brain tissues before and after irradiation. The conductivity images, which showed significantly higher sensitivity than other MR imaging methods, indicated that the contrast is distinguishable in different ways at different areas of the brain. Future studies will focus on verifying these results and the long-term evaluation of conductivity changes using various irradiation methods for clinical applications.Author information
Park JA, Woo EJ, Kang KJ, Ko IO, Lee KC, Choi BK, Katoch N, Kim JW, Kim HJ, Kwon OI.
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