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Abstract
PURPOSE:
To evaluate the preventive effect of parotid gland (PG) massage for PG damage during the I therapy, we prospectively investigated the serum amylase value and salivary gland scintigraphy (SGS) after I therapy.

MATERIALS AND METHODS:
One hundred patients with thyroidectomized differentiated thyroid cancer who underwent high-dose I therapy were enrolled in the clinical trial and randomized into 2 groups (PG massage group and nonmassage group). The serum amylase value was obtained before and 24 hours after I therapy, and the SGSs were also taken just before and at 8 months after the I therapy. Change in serum amylase value and SGS was compared between PG massage and nonmassage groups.

RESULTS:
The difference value of serum amylase was significantly lower in PG massage group than in nonmassage group (P = 0.0052). Worsening of PG function on SGS was observed in 43 (45.3%) of the 95 patients. The incidence rate of PG abnormality on F/U SGS was significantly lower in PG massage group than in nonmassage group (odds ratio, 0.3704; P = 0.0195). In the multiple regression analysis, PG massage significantly affected the abnormality on the 8-month F/U SGS (rpartial = -0.2741, P = 0.0090) after adjusting for clinical variables (age, sex, TNM stage, TSH preparation methods for the I therapy, and I dose).

CONCLUSIONS:
PG gland massage significantly reduced the incidence rates of salivary gland dysfunction on the 8-month F/U SGS and the level of the serological marker of salivary gland destruction after I therapy. Therefore, PG gland massage could alleviate salivary gland damage related to I therapy.

그림. 갑상선스캔 상 마사지를 시행한 군에서 이하선의 손상빈도가 낮게 발생함을 보여준 그래프임.

Author information

Son SH1,2, Lee CH1,2, Jung JH1,2, Kim DH1,2, Hong CM1,2, Jeong JH1,2, Jeong SY1,2, Lee SW1,2, Lee J1,2, Ahn BC1,2.
1
From the Department of Nuclear Medicine, School of Medicine, Kyungpook National University.
2
Department of Nuclear Medicine, Kyungpook National University Hospital, Daegu, Republic of Korea.