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방사선종양학
- 2024년 02월호
[Cancers (Basel) .] Treatment Outcomes after Dose-Escalated Moderately Hypofractionated Radiotherapy for Frail Patients with High-Grade Glioma성균관의대 / 김나리, 신현주, 임도훈*
- 출처
- Cancers (Basel) .
- 등재일
- 2023 Dec 21
- 저널이슈번호
- 16(1):64. doi: 10.3390/cancers16010064.
- 내용
Abstract
For high-grade glioma (HGG) patients with old age or poor performance status, hypofractionated radiotherapy (hypoRT) in 10-15 fractions is recommended. Also, limited data exist on the impact of salvage treatment after progression in frail patients. We retrospectively analyzed the outcomes of dose-escalated hypoRT in 40 frail HGG patients who were treated with hypoRT between 2013 and 2021. With a median biologically effective dose of 71.7 Gy, a total dose of 56 Gy in 20 fractions was the most frequently used regimen (53.7%). The median age and Karnofsky Performance Status of patients were 74 years and 70, respectively. Most patients (n = 31, 77.5%) were diagnosed with glioblastoma, IDH-wildtype, CNS WHO grade 4. Only 10 (25.0%) patients underwent surgical resection, and 28 (70.0%) patients received concurrent temozolomide during hypoRT. With a median follow-up of 9.7 months, the median overall survival (OS) was 12.2 months. Of the 30 (75.0%) patients with disease progression, only 12 patients received salvage treatment. The OS after progression differed significantly depending on salvage treatment (median OS, 9.6 vs. 4.6 months, p = 0.032). Dose-escalated hypoRT in 20 fractions produced survival outcomes outperforming historical data for frail patients.Affiliations
Nalee Kim 1, Hyunju Shin 1, Do Hoon Lim 1, Do-Hyun Nam 2, Jung-Il Lee 2, Ho Jun Seol 2, Doo-Sik Kong 2, Jung Won Choi 2, Kyuha Chong 2, Won Jae Lee 2
1Department of Radiation Oncology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul 06351, Republic of Korea.
2Department of Neurosurgery, Brain Tumor Center, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul 06351, Republic of Korea.
- 키워드
- brain tumor; frail patients; hypofractionation; radiotherapy.
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편집위원
노령이거나 수행 상태가 좋지 않은 고등급 신경교종(HGG) 환자의 경우 10~15분할의 저분할 방사선 요법(hypoRT)이 권장되는 상황에서 56Gy/20fx 진행한 환자군이 유의한 생존율 향상을 보였음. 수행상태가 좋지않은 환자에서도 escalated RT가 효과가 있음이 흥미로움.
덧글달기닫기2024-02-05 16:40:01
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