아주의대 / 김상원, 전미선*
Abstract
We compared the cumulative incidence of ipsilateral breast tumor recurrence (IBTR) between 2 whole breast irradiation (WBI) dose range with conventional fractionation.We retrospectively reviewed 1122 patients who received WBI at 2 institutions between 2004 and 2012. One institution delivered WBI 41.4 to 45 Gy followed by boost 14 to 18 Gy (adjusted group), while the other delivered WBI 50 to 50.4 Gy followed by boost 10 Gy (standard group).The median follow-up period was 85 months. The 10-year cumulative incidence in all patients was 6.1% (95% confidence interval [CI]: 4.3%-8.4%) for IBTR and 3.0% (95% CI: 1.7%-4.8%) for regional recurrence. The 10-year cumulative incidence of IBTR was not significantly influenced by WBI dose (6.3% in the adjusted group vs 5.2% in the standard group, P = .136). Comparable IBTR rates between the 2 groups were observed regardless of clinical and pathological factors. The WBI dose was not significantly associated with the 10-year cumulative incidence of regional recurrence in these groups (3.5% in the adjusted group vs 0.5% in the standard group, P = .214).De-escalated WBI doses while intensifying tumor bed boost did not compromise local and regional outcomes compared to standard group.
Affiliations
Sang-Won Kim 1 2 , Mison Chun 1 , Young-Taek Oh 1 , O Kyu Noh 1 3
1 Department of Radiation Oncology, Ajou University School of Medicine, Suwon.
2 Department of Radiation Oncology, Myunggok Medical Research Institute, Konyang University College of Medicine, Daejeon.
3 Department of Bioinformatics, Ajou University School of Medicine, Suwon, Republic of Korea.
편집위원
통상분할조사를 이용한 전유방방사선치료 선량을 50-50.4 Gy에서 41.4-45 Gy로 줄이고, 대신 tumor bed boost 선량을 10 Gy에서 14-18 Gy로 증가시켰을 때, 국소영역 재발률의 차이가 없음을 보고함.
2020-07-02 14:18:02