방사선종양학

  • [Cancer Res Treat.] Korean First Prospective Phase II Study, Feasibility of Prone Position in Postoperative Whole Breast Radiotherapy: A Dosimetric Comparison.

    성균관의대 / 정윤선, 최두호*

  • 출처
    Cancer Res Treat.
  • 등재일
    2019 Oct
  • 저널이슈번호
    51(4):1370-1379. doi: 10.4143/crt.2018.423. Epub 2019 Feb 18.
  • 내용

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    Abstract
    PURPOSE:
    This first Korean prospective study is to evaluate the feasibility of prone breast radiotherapy after breast conserving surgery for left breast cancer patients who have relatively small breast size and we present dosimetric comparison between prone and supine positions.

    Materials and Methods:
    Fifty patients underwent two computed tomography (CT) simulations in supine and prone positions. Whole breast, ipsilateral lung, heart, and left-anterior-descending coronary artery were contoured on each simulation CT images. Tangential-fields treatment plan in each position was designed with total 50 Gy in 2-Gy fractions, and then one of the positions was designated for the treatment by comparing target coverage and dose to normal organs. Also, interfractional and intrafractional motion was evaluated using portal images.

    RESULTS:
    In total 50 patients, 32 cases were decided as prone-position-beneficial group and 18 cases as supine-position-beneficial group based on dosimetric advantage. Target dose homogeneity was comparable, but target conformity in prone position was closer to optimal than in supine position. For both group, prone position significantly increased lung volume. However, heart volumewas decreased by prone position for prone-position-beneficial group but was comparable between two positions for supine-position-beneficial group. Lung and heart doses were significantly decreased by prone position for prone-position-beneficial group. However, prone position for supine-position-beneficial group increased heart dose while decreasing lung dose. Prone position showed larger interfractional motion but smaller intra-fractional motion than supine position.

    CONCLUSION:
    Prone breast radiotherapy could be beneficial to a subset of small breast patients since it substantially spared normal organs while achieving adequate target coverage.

     


    Author information

    Chung Y1, Yu JI2, Park W2, Choi DH2.
    1
    Department of Nuclear Engineering, Hanyang University, Seoul, Korea.
    2
    Department of Radiation Oncology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.

     

  • 키워드
    Clinical trial; Left-sided breast neoplasms; Prone position; Radiotherapy
  • 편집위원

    국내에서 처음으로 유방암 prone RT의 장단점을 전향적으로 평가한 논문

    2020-01-03 15:37:52

  • 편집위원2

    국내 최초의 Prone Breast 방사선치료에 대한 Randomize trial. Prone breast 방사선치료의 가능성에 대한 결과

    2020-01-03 15:55:22

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