방사선종양학

  • [Breast Cancer Res Treat.] Survival benefit of postoperative radiotherapy for ductal carcinoma in situ after breast-conserving surgery: a Korean population-based cohort study.

    서울특별시보라매병원 / 김병혁, 황기태*

  • 출처
    Breast Cancer Res Treat.
  • 등재일
    2019 Nov
  • 저널이슈번호
    178(1):105-113. doi: 10.1007/s10549-019-05372-z. Epub 2019 Jul 25.
  • 내용

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    Abstract
    PURPOSE:
    It has been accepted that radiation therapy (RT) for ductal carcinoma in situ (DCIS) has no survival benefit despite increasing local control. However, a recent large database study reported a small but significant benefit. Using a Korean population-based large database, we examined the survival benefit of RT for DCIS after breast-conserving surgery (BCS) and analyzed which subgroup might derive benefit from it.

    METHODS:
    Data from 6038 female DCIS patients who underwent BCS with or without RT between 1993 and 2012 were included in this study. We used propensity score analysis to control for differences in baseline characteristics.

    RESULTS:
    Before adjusting, patients who received RT were more likely to have a large-sized tumor, poor histologic grade, poor nuclear grade, and less hormone receptor positivity. Ten-year overall survival (OS) rates were 95.0% in the non-RT group and 97.1% in the RT group (p < 0.001). After adjusting, previously noted differences of characteristics were substantially reduced, and then ten-year OS rates were 94.3% in the non-RT group and 97.6% in the RT group (p = 0.001). When examining the benefit of RT according to proposed prognostic scores, patients with a score of 0 showed no difference in OS by adding RT after BCS, whereas those with high scores demonstrated a significant benefit.

    CONCLUSIONS:
    We demonstrated the significant OS benefit of postoperative RT after BCS based on a large database, and for the first time beyond the western population. The omission of RT for selected patients to prevent overtreatment needs to be more elaborately studied.

     


    Author information

    Kim BH1, Ko BK2, Bae JW3, Nam S4, Park MH5, Jeong J6, Lee HJ7, Chang JH1, Kim S1, Hwang KT8.
    1
    Department of Radiation Oncology, Seoul Metropolitan Government Seoul National University Boramae Medical Center, Seoul, Republic of Korea.
    2
    Department of Surgery, Ulsan University Hospital, University of Ulsan College of Medicine, Ulsan, Republic of Korea.
    3
    Department of Surgery, Korea University Anam Hospital, Seoul, Republic of Korea.
    4
    Department of Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea.
    5
    Department of Surgery, Chonnam National University Medical School, Kwangju, Republic of Korea.
    6
    Department of Surgery, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, Republic of Korea.
    7
    Breast and Thyroid Clinic, Segyero Hospital, Pusan, Republic of Korea.
    8
    Department of Surgery, Seoul Metropolitan Government Seoul National University Boramae Medical Center, 20 Boramae-ro 5-gil, Dongjak-gu, Seoul, 07061, Republic of Korea. kiterius@snu.ac.kr.

  • 키워드
    Breast-conserving surgery; Ductal carcinoma in situ; Postoperative radiotherapy
  • 편집위원

    국내의 대규모 등록자료를 이용하여 DCIS에서 postop RT가 생존율을 향상시키는 잇점이 있음을 증명한 논문

    2020-01-03 15:38:33

  • 편집위원

    한국인유방암환자 빅데이터를 기반으로 DCIS에서 postop RT의 생존율 향상을 보고한 연구입니다.

    2020-01-03 15:42:28

  • 편집위원3

    불필요한 방사선치료는 최소화하는 분위기에서 DCIS에서 방사선치료가 생존기간을 증가시킨다는 다른 방향의 결과를 보여주고 있어서 흥미롭습니다.

    2020-01-03 15:44:31

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