방사선종양학

  • [Head Neck.] Patterns of local recurrence after curative resection and reconstruction for oropharyngeal and oral cancers: Implications for postoperative radiotherapy target volumes.

    연세의대 / 조연아, 금기창*

  • 출처
    Head Neck.
  • 등재일
    2019 Nov
  • 저널이슈번호
    41(11):3916-3923. doi: 10.1002/hed.25928. Epub 2019 Aug 20.
  • 내용

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    Abstract
    BACKGROUND:
    We aimed to determine the patterns of local recurrence after curative resection and reconstruction for oropharyngeal and oral cancers.

    METHODS:
    One hundred-fourteen patients with oropharyngeal and oral cancers underwent resection and reconstruction. The local recurrences were classified as "intra-flap" (the recurrent tumor was located in the flap tissue), "marginal" (≤5 mm from the flap anastomosis), and "outside" (in the original tissue and >5 mm from the anastomosis) recurrences.

    RESULTS:
    Twenty-seven patients (23.7%) experienced local recurrence, while 32 (28.1%) experienced regional, and nine (7.9%) recurred distantly. Among those who showed local recurrence, one developed "outside" recurrence and the remaining 26 developed "marginal" recurrences. Age >60 years and lymph node metastasis were associated with poor disease-free survival and overall survival (OS), while the perineural invasion was related to poor locoregional failure-free survival and OS.

    CONCLUSION:
    Most recurrences developed at the anastomosis marginal site, while none developed in the flap tissue.

     


    Author information

    Cho Y1, Yoon HI2, Lee IJ1, Kim JW1, Lee CG2, Choi EC3, Kim SH3, Keum KC2.
    1
    Department of Radiation Oncology, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, South Korea.
    2
    Department of Radiation Oncology, Yonsei Cancer Center, Yonsei University College of Medicine, Seoul, South Korea.
    3
    Department of Otorhinolaryngology, Head and Neck Surgery, Yonsei University College of Medicine, Seoul, South Korea.

  • 키워드
    oral cancer; oropharyngeal cancer; reconstruction; recurrence; surgery
  • 편집위원

    비록 적은수의 환자를 대상으로 분석하였지만, 구인두와 구강암환자에서 수술시 재건술을 시행한 후 재발 양상을 관찰하였을 때, flap 보다는 flap anastomosis 부위에서 대부분 재발한다는 결과는 target contouring시 도움이 될 것으로 생각합니다.

    2020-01-03 15:43:01

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