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  • [Gynecol Oncol.] Radiotherapy is a safe and effective salvage treatment for recurrent cervical cancer.

    연세의대 / 김현주, 김용배*

  • 출처
    Gynecol Oncol.
  • 등재일
    2018 Nov
  • 저널이슈번호
    151(2):208-214. doi: 10.1016/j.ygyno.2018.08.029. Epub 2018 Sep 6.
  • 내용

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    Abstract
    OBJECTIVE:
    The feasibility of salvage radiotherapy (RT) for patients with recurrent cervical cancer after definitive treatment is contentious. The purpose of this study was to investigate the feasibility and benefit of RT, particularly intensity-modulated RT (IMRT), for salvage treatment in patients with recurrent cervical cancer.

    METHODS:
    We retrospectively analyzed 125 patients with recurrent cervical cancer treated with RT at Yonsei Cancer Center between January 2007 and December 2016. All patients received salvage RT for the recurred or metastatic tumor mass. Irradiating dose and volume were determined depending on initial treatment. IMRT was selected in challenging cases, such as re-irradiation or for patients for whom implementing a satisfactory 3-dimensional conformal RT plan was challenging.

    RESULTS:
    The median follow-up period was 5.5 years (range, 10.8 months to 41 years). The 5-year local failure-free survival (LFFS) and progression-free survival (PFS) rates were 63.9% and 39.6%, respectively. The 5-year overall survival (OS) rate was 66%; 10-year OS reached 51%. The median PFS rates in patients with locoregional failure, distant metastases, or both were 45.4, 29.1, and 14.7 months, respectively (p = 0.005). For the 45 patients that received re-irradiation, 5-year LFFS, PFS, and OS rates were 47.1%, 33.2%, and 66.5%, respectively. Late complications were observed in 12 patients (12/125, 9.6%).

    CONCLUSIONS:
    Our data suggest that salvage RT is safe and effective against recurrent cervical cancer. IMRT is a safe and effective salvage modality for these patients, including those requiring re-irradiation.

     


    Author information

    Kim HJ1, Chang JS2, Koom WS3, Lee KC4, Kim GE5, Kim YB6.
    1
    Department of Radiation Oncology, Gachon University Gil Medical Center, 774 Namdongdae-ro, Incheon 21565, Republic of Korea. Electronic address: hjkim@gilhospital.com.
    2
    Department of Radiation Oncology, Yonsei Cancer Center, Yonsei University College of Medicine, 50-1 Yonsei-ro, Seodaemun-gu, Seoul 03722, Republic of Korea. Electronic address: changjeesuk@yuhs.ac.
    3
    Department of Radiation Oncology, Yonsei Cancer Center, Yonsei University College of Medicine, 50-1 Yonsei-ro, Seodaemun-gu, Seoul 03722, Republic of Korea. Electronic address: mdgold@yuhs.ac.
    4
    Department of Radiation Oncology, Gachon University Gil Medical Center, 774 Namdongdae-ro, Incheon 21565, Republic of Korea. Electronic address: kyu22@gilhospital.com.
    5
    Department of Radiation Oncology, Jeju National University Hospital, Jeju National University School of Medicine, Aran 13gil-15, Jeju 63241, Republic of Korea. Electronic address: gekim@yuhs.ac.
    6
    Department of Radiation Oncology, Yonsei Cancer Center, Yonsei University College of Medicine, 50-1 Yonsei-ro, Seodaemun-gu, Seoul 03722, Republic of Korea. Electronic address: ybkim3@yuhs.ac.

  • 키워드
    Cervical cancer; Intensity-modulated; Radiotherapy; Recurrence; Salvage therapy
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