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  • [Cancer Res Treat.] Breast Conservation Therapy Versus Mastectomy in Patients with T1-2N1 Triple-Negative Breast Cancer: Pooled Analysis of KROG 14-18 and 14-23.

    서울의대, 성균관의대 / 김규보, 신경환*, 박원*

  • 출처
    Cancer Res Treat.
  • 등재일
    2018 Oct
  • 저널이슈번호
    50(4):1316-1323. doi: 10.4143/crt.2017.575. Epub 2018 Jan 8.
  • 내용

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    Abstract
    PURPOSE:
    The aim of this study is to compare the treatment outcomes of breast conserving surgery (BCS) plus radiotherapy (RT) versus mastectomy for patients with pT1-2N1 triple-negative breast cancer (TNBC).

    Materials and Methods:
    Using two multicenter retrospective studies on breast cancer, a pooled analysis was performed among 320 patients with pT1-2N1 TNBC. All patients who underwent BCS (n=212) receivedwhole breast RTwith orwithoutregional nodal RT,while nonewho underwent mastectomy (n=108)received it. All patients received taxane-based adjuvant chemotherapy. The median follow-up periods were 65 months in the BCS+RT group, and 74 months in the mastectomy group.

    RESULTS:
    The median age of all patients was 48 years (range, 24 to 70 years). Mastectomy group had more patients with multiple tumors (p < 0.001), no lymphovascular invasion (p=0.001), higher number of involved lymph node (p=0.028), and higher nodal ratio ≥ 0.2 (p=0.037). Other characteristics were not significantly different between the two groups. The 5-year locoregionalrecurrence-free, disease-free, and overall survivalrates of BCS+RT group versus mastectomy group were 94.6% versus 87.7%, 89.5% versus 80.4%, and 95.0% versus 87.8%, respectively, and the differences were statistically significant after adjusting for covariates (p=0.010, p=0.006, and p=0.005, respectively).

    CONCLUSION:
    In pT1-2N1 TNBC, breast conservation therapy achieved better locoregional recurrencefree, disease-free, and overall survival rates compared with mastectomy.

     


    Author information

    Kim K1, Park HJ2, Shin KH3, Kim JH3, Choi DH4, Park W4, Ahn SD5, Kim SS6, Kim DY6, Kim TH6, Kim JH7, Kim J1.
    1
    Department of Radiation Oncology, Ewha Womans University College of Medicine, Seoul, Korea.
    2
    Department of Radiation Oncology, Hanyang University College of Medicine, Seoul, Korea.
    3
    Department of Radiation Oncology, Seoul National University College of Medicine, Seoul, Korea.
    4
    Department of Radiation Oncology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.
    5
    Department of Radiation Oncology, Asan Medical Center, Ulsan University College of Medicine, Seoul, Korea.
    6
    Proton Therapy Center, Research Institute and Hospital, National Cancer Center, Goyang, Korea.
    7
    Department of Radiation Oncology, Dongsan Medical Center, Keimyung University School of Medicine, Daegu, Korea.

  • 키워드
    Breast conservation therapy; Mastectomy; Triple negative breast neoplasms
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