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  • [Cancer Res Treat.] Clinical Practice Patterns of Radiotherapy in Patients with Hepatocellular Carcinoma: A Korean Radiation Oncology Group Study (KROG 14-07).

    연세의대 / 차현정, 성진실*

  • 출처
    Cancer Res Treat.
  • 등재일
    2017 Jan
  • 저널이슈번호
    49(1):61-69. doi: 10.4143/crt.2016.097. Epub 2016 Jun 13.
  • 내용

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    Abstract

    PURPOSE:

    The aim of this study was to examine patterns of radiotherapy (RT) in Korean patients with hepatocellular carcinoma (HCC) according to the evolving guideline for HCC established by the Korean Liver Cancer Study Group-National Cancer Center (KLCSG-NCC).

     

    MATERIALS AND METHODS:

    We reviewed 765 patients with HCC who were treated with RT between January 2011 and December 2012 in 12 institutions.

     

    RESULTS:

    The median follow-up period was 13.3 months (range, 0.2 to 51.7 months). Compared with previous data between 2004 and 2005, the use of RT as a first treatment has increased (9.0% vs. 40.8%). Increased application of intensity-modulated RT resulted in an increase in radiation dose (fractional dose, 1.8 Gy vs. 2.5 Gy; biologically effective dose, 53.1 Gy10 vs. 56.3 Gy10). Median overall survival was 16.2 months, which is longer than that reported in previous data (12 months). In subgroup analysis, treatments were significantly different according to stage (p < 0.001). Stereotactic body RT was used in patients with early HCC, and most patients with advanced stage were treated with three-dimensional conformal RT.

     

    CONCLUSION:

    Based on the evolving KLCSG-NCC practice guideline for HCC, clinical practice patterns of RT have changed. Although RT is still used mainly in advanced HCC, the number of patients with good performance status who were treated with RT as a first treatment has increased. This change in practice patterns could result in improvement in overall survival.


    Author information

    Cha H1,2, Park HC2,3, Yu JI2, Kim TH4, Nam TK5, Yoon SM6, Yoon WS7, Kim JW8, Kim MS9, Jang HS10, Choi Y11, Kim JH12, Kay CS13, Jung I14, Seong J1.

    1Department of Radiation Oncology, Yonsei Cancer Center, Yonsei University College of Medicine, Seoul, Korea.
    2Department of Radiation Oncology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.
    3Department of Medical Device Management and Research, SAIHST, Sungkyunkwan University, Seoul, Korea.
    4Research Institute and Hospital, National Cancer Center, Goyang, Korea.
    5Department of Radiation Oncology, Chonnam National University Medical School, Gwangju, Korea.
    6Department of Radiation Oncology, Asan Liver Center, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.
    7Department of Radiation Oncology, Korea University Ansan Hospital, Ansan, Korea.
    8Department of Radiation Oncology, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, Korea.
    9Department of Radiation Oncology, Korea Institute of Radiological and Medical Sciences, Seoul, Korea.
    10Department of Radiation Oncology, College of Medicine, The Catholic University of Korea, Seoul, Korea.
    11Department of Radiation Oncology, Dong-A University College of Medicine, Busan, Korea.
    12Department of Radiation Oncology, Keimyung University Dongsan Medical Center, Keimyung University School of Medicine, Daegu, Korea.
    13Department of Radiation Oncology, Incheon St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Incheon, Korea.
    14Department of Biostatistics, Severance Hospital, Yonsei University College of Medicine, Seoul, Korea.

     

  • 키워드
    Clinical practice pattern; Hepatocellular carcinoma; Radiotherapy
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